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Aspartame and FDA Annotated Bibliography

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OpEdNews
April 9, 2008
By Stephen Fox
Open Letter by Dr. Betty Martini

To Legislators: Corroborating references for Senate Concurrent Resolution 191, Senator Suzanne Chun Oakland

To Honorable Senator David Ige and the Honorable Lorraine Inouye, Co-chairs, Joint Health/Intergovernmental Affairs Committee and Members of the Committee

Dear Senator Ige, Senator Inouye, and Members of the Committee:

It has come to my attention that you want references to the resolution to corroborate all of the "whereases" in the resolution. I'm very happy to give you these, and you will find them in caps below the comments. I will also fax you some of the documents. Had you asked earlier, at any time in the prior 25 days, we would have been able to gladly send you this background information.

Please feel free to ask for any additional information you would like to have. I trust that by this time, you have taken the time to watch Sweet Misery, submitted by Adrian Chang as part of his official testimony on the prior Senate bill by Kalani English, concerning a statutory ban, the bill you decided to defer, which resulted in this vital resolution.

This documentary contains comments and footage of the top physicians in the world on this subject, as well as of James Turner, Atty, explaining how aspartame was marketed after originally the FDA said no. This was through the political chicanery of Don Rumsfeld. Here is the clip from the film where James Turner explains:

click here

Also, Dr. Bill Deagle has recently written a new report on aspartame which you can access from his web site:
click here

If you click on more information at the bottom there are probably 50 pages of references. When the committee meeting is set up there is opportunity for video conference with Dr. Deagle and other world experts.

To make sure you have seen MP Roger Williams' report from Britain on 47 members of Parliament who signed for a ban here is his material: "UK Parliamentary Information Management Services [PIMS ] Early Day Motion EDM 1517

TOXIC PROPERTIES OF ASPARTAME 30.01.2006 January 30, 2006

Williams, Roger

That this House expresses deep concern over the numerous independent toxicological studies and thousands of subjective reports attesting to the toxic effects of the artificial sweetener aspartame on human health; notes that aspartame, once patented as a biochemical warfare agent, is the synthetically produced methyl ester of a dipeptide which is readily broken down in the gut to release methanol; further notes that in naturally occurring foodstuff methanol is either not released into the body or present together with natural defence mechanisms that mitigate its toxic effects; recognises that methanol is a well known poison and is further converted into formaldehyde, a class A carcinogen according to the World Health Organisation's International Agency for Research on Cancer; accepts that severe health concerns occur from the gradual accumulation of formaldehyde in the body which cannot be excreted and that further research has shown that long term low level exposure to formaldehyde induces leukaemia and nasopharyngeal cancer in humans; acknowledges that of the 166 studies conducted on aspartame safety deemed relevant to humans, 92 per cent. of independently sponsored studies identified one or more problems with aspartame's safety whereas industry-sponsored studies found unanimously in favour of aspartame's safety; and urges the Government to abide by the precautionary principle and make use of Statutes 13 and 16 of the 1990 Food Safety Act to remove aspartame from the permitted list of additives on the UK market."

Signatures( 47)

HAWAII SENATE RESOLUTION ON ASPARTAME BY SENATOR CHUN OAKLAND,

Text of Senate Resolution:

Requesting the Department of Health and the National Academy of Sciences to review existing reports and studies related to Aspartame, and Requesting the United States Food and Drug Administration to Rescind Approval for United States Markets, carried by Hawaii Senator Suzanne Chun Oakland.
___________________________________________________________

Whereas, aspartame was originally developed as a drug to treat peptic ulcers; and Whereas, manufacturers state that aspartame is made up of forty per cent aspartic acid, fifty percent phenylalanine, and ten per cent methanol; and

DEVELOPED AS AN ULCER DRUG IS ON PAGE 36 OF ECOLOGIST. SOME OF YOU WERE GIVEN A COPY. HERE IS THE URL FOR THE COMPLETE TEXT OF THIS ARTICLE:

www.mpwhi.com/ecologist_september_2005.pdf

ALSO IN "HISTORY OF ASPARTAME" BY ARTHUR EVANGELISTA, FORMER FDA INVESTIGATOR, WHICH INCLUDES THE 8 MONTH UPI INVESTIGATION BY GREGORY GORDON

http://www.wnho.net/history_of_aspartame.htm

COMPONENTS OF ASPARTAME IN MEDICAL TEXT, ASPARTAME DISEASE: AN IGNORED EPIDEMIC, BY H. J. ROBERTS, MD, www.sunsentpress.com (REP JOSH GREEN, M.D. HAS A COPY YOU ARE WELCOME TO LOOK AT.)

Whereas, aspartic acid is a nonessential amino acid that is used by the body to initiate apoptosis or cell death in aging cells, and that excess aspartic acid from aspartame consumption causes apoptosis in healthy cells that can destroy healthy tissue, especially in the brain; and

APOPTOSIS IS PROGRAMMED CELL DEATH OR CELL SUICIDE. IT IS DISCUSSED IN GREAT DETAIL IN EXCITOTOXINS; THE TASTE THAT KILLS BY NEUROSURGEON RUSSELL BLAYLOCK, M.D.,
www.russellblaylockmd.com

A NEW STUDY ON ASPARTAME JUST RELEASED, DIRECT AND INDIRECT CELLULAR EFFECTS OF ASPARTAME ON THE BRAIN HAS JUST PROVEN APOPTOSIS AGAIN, click here

DR. BILL DEAGLE MENTIONS ASPARTAME AND APOPTOSIS IN HIS NOTE ON ASPARTAME AND PILOTS ADDED TO DR. BLAYLOCK'S REPORT: http://www.mpwhi.com/pilot_aspartame_alert.htm

COMPLETE INFORMATION ON THE DAMAGE OF ASPARTIC ACID AS AN ISOLATE IN ASPARTAME:
http://www.wnho.net/aspartame_brain_damage.htm BY FORMER FDA INVESTIGATOR ARTHUR EVANGELISTA AND JAMES BOWEN, M.D.

________________________________________________

Whereas, phenylalanine is an essential amino acid found naturally in protein but when isolated becomes neurotoxic, lowers the seizure threshold, depletes serotonin triggering psychiatric and behavioral problems, and interacts with depressants and other drugs; and

FROM RALPH WALTON, M.D., PSYCHIATRIST, WHO DID A STUDY ON ASPARTAME: ASPARTAME AND PSYCHIATRIC DISEASE:
click here

CHAPTER ON DRUG INTERACTION AND PSYCHIATRIC AND BEHAVIORAL PROBLEMS, ASPARTAME DISEASE; AN IGNORED EPIDEMIC, www.sunsentpress.com

H. J. ROBERTS, M.D. BOOK ON THE SUBJECT, DIETARY PHENYLALANINE AND BRAIN FUNCTION, RICHARD J. WURTMAN, BIRKHAUSER. HERE IS ONE OF DR. WURTMAN'S PAPERS EXPLAINING PHENYLALANINE AND THAT DRUGS INTERACT WITH IT. HE DISCUSSES THE SEIZURES AS WELL. http://www.dorway.com/wurtman86.html
________________________________________

Whereas, methanol is a severe metabolic poison classified as a narcotic that converts to formaldehyde and formic acid, and can embalm living tissue and damage DNA; and

METHANOL, A SEVERE METABOLIC POISON CLASSIFIED AS A NARCOTIC: LOUIS, R. J. SAX'S DANGEROUS PROPERTIES OF INDUSTRIAL MATERIALS, EIGHTH EDITION, NEW YORK: VAN NOSTRAND REINHOLD (1992) PP. 2251-2252.

THE TROCHO STUDY PROVES THE FORMALDEHYDE EMBALMS LIVING TISSUE AND DAMAGES DNA. http://www.mpwhi.com/formaldehyde_from_aspartame.pdf

THE MEDICAL TEXT ASPARTAME DISEASE; AN IGNORED EPIDEMIC, H. J. ROBERTS, M.D., www.sunsentpress.com DISCUSSES METHANOL CONVERTING TO FORMALDEHYDE AND FORMIC ACID.

Whereas, aspartame metabolites include formaldehyde, a class A carcinogen, diketopiperazine, a brain tumor agent, and formic acid, and

FORMALDEHYDE, A CLASS A CARCINOGEN:
www.mpwhi.com/formaldehyde_from_aspartame_press_release.pdf BY DR. WOODROW MONTE. HE ALSO WROTE ASPARTAME; METHANOL AND THE PUBLIC HEALTH, A PEER REVIEWED JOURNAL ARTICLE: http://www.dorway.com/monte84.html

HERE IS THE SECRET TRADE INFORMATION SUBMITTED IN CONGRESSIONAL HEARINGS. IT READS LIKE PSYCHOMANIPULATION TO GET ASPARTAME APPROVED. IN THE LAST PARAGRAPH THEY ADMIT TO ALMOST COMPLETE CONVERSION OF DKP, THE BRAIN TUMOR AGENT, AND DON'T WANT THE FDA TO KNOW. http://dorway.com/dorwblog/?page_id=48

DIKETOPIPERAZINE IS DISCUSSED IN DETAIL IN ASPARTAME DISEASE; AN IGNORED EPIDEMIC, www.sunsentpress.com BY H. J. ROBERTS, M.D.

ALSO IN EXCITOTOXINS; THE TASTE THAT KILLS BY NEUROSURGEON RUSSELL BLAYLOCK, MD, PAGE 212, www.russellblaylockmd.com
__________________________________________

Whereas, in 1974, the United States Food and Drug Administration approved aspartame as an artificial sweetener, but asked its manufacturer Searle to hold back from selling it on the market until further tests could be made with regards to its safety; and

ECOLOGIST AS REFERENCED ABOVE. ALSO THE BOOK RUMSFELD, HIS RISE, FALL AND CATASTROPHIC LEGACY, BY ANDREW COCKBURN, CHAPTER 4, HOW SWEET IT IS, PAGE 62
_____________________________________

Whereas, scientific data revealed that there was a problem with aspartame safety date and the United States Food and Drug Administration withdrew its approval; and

HERE IS THE ACTUAL BOARD OF INQUIRY REPORT REVOKING THE PETITION FOR ASPARTAME:
http://www.mpwhi.com/fda_petition1.doc
_______________________________________

Whereas, in 1975, the United States Food and Drug Administration initiated an investigation into Searle's laboratory practices and discovered fraud in scientific experiments as well as manipulated data giving favorable results proving aspartame to be safe; and

IN JULY, 1975, FDA COMMISSIONER, DR ALEXANDER SCHMIDT APPOINTED A SPECIAL TASK FORCE TO LOOK AT 25 KEY STUDIES FOR THE DRUGS FLAGYL, ALDACTONE, NORPACE AND THE FOOD ADDITIVE ASPARTAME. ELEVEN OF THE PIVOTAL STUDIES EXAMINED INVOLVED ASPARTAME. ALL OF THE STUDIES WHETHER CONDUCTED AT G. D. SEARLE OR HAZLETON LABS WERE THE RESPONSIBILITY OF THE PATHOLOGY TOXICOLOGY DEPARTMENT AT G. D. SEARLE. (GROSS l987A,, PAGE 430 OF US SENATE 1987).

THE SPECIAL TASK FORCE WAS HEADED BY PHILIP BRODSKY, FDA'S LEAD INVESTIGATOR AND ASSISTED BY FDA TOXICOLOGIST, DR ADRIAN GROSS. G. D. SEARLE EXECUTIVES ADMITTED TO "PAYMENTS TO EMPLOYEES OF CERTAIN FOREIGN GOVERNMENTS TO OBTAIN SALES OF THEIR PRODUCTS." (SEARLE 1976) ON JULY 10, 1975, SENATOR EDWARD KENNEDY CHAIRED A HEARING ON DRUG RELATED RESEARCH BEFORE THE SENATE SUBCOMMITTEE ON HEALTH OF THE COMMITTEE ON LABOR AND PUBLIC WELFARE (US SENATE 1975) PRELIMINARY REPORTS OF DISCREPANCIES DISCOVERED ABOUT G. D. SEARLE WERE DISCUSSED. THE FINDINGS OF THE FDA TASK FORCE WERE LATER PRESENTED AT FURTHER HEARINGS ON JANUARY 20, 1976 (US SENATE 1976 a) AND APRIL 8, 1976 (US SENATE 1976b). ON DECEMBER 8, 1975, STOCKHOLDERS FILED A CLASS ACTION LAWSUIT ALLEGING THAT G. D. SEARLE HAD CONCEALED INFORMATION FROM THE PUBLIC REGARDING THE NATURE AND QUALITY OF ANIMAL RESEARCH AT G. D. SEARLE IN VIOLATION OF THE SECURITIES AND EXCHANGE ACT (FARBER 1989, PAGE 48)

ON MARCH 24, 1976 THE FDA'S TASK FORCE REPORTS, "AT THE HEART OF THE FDA'S REGULATORY PROCESS IS ITS ABILITY TO RELY UPON THE INTEGRITY OF THE BASIC SAFETY DATA SUBMITTED BY SPONSORS OF REGULATED PRODUCTS. OUR INVESTIGATION CLEARLY DEMONSTRATES THAT, IN THE G. D. SEARLE COMPANY, WE HAVE NO BASIS FOR SUCH RELIANCE NOW."

THE TASK FORCE FURTHER SAYS, "SOME OF OUR FINDINGS SUGGEST AN ATTITUDE OF DISREGARD FOR FDA'S MISSION OF PROTECTION OF THE PUBLIC HEALTH BY SELECTIVELY REPORTING THE RESULTS OF STUDIES IN A MANNER WHICH ALLAYS THE CONCERNS OF QUESTIONS OF AN FDA REVIEWER." REFERENCE: FOOD AND DRUG ADMINISTRATION SEARLE INVESTIGATION TASK FORCE CHAIRED BY CARLTON SHARP. "FINAL REPORT OF INVESTIGATION OF G. D. SEARLE COMPANY" (MARCH 24, 1976).
_____________________________

Whereas, the results of this investigation are included in what is called The Bressler Report by Jerome Bressler; and Whereas, in 1980, Dr. John Olney submitted scientific data to a United States Food and Drug Administration Public Board of Inquiry showing that aspartic acid, the excitotoxic ingredient in aspartame, caused holes in the brains of mice; and

BRESSLER REPORT: http://www.dorway.com/bressler.txt

DR JOHN OLNEY TESTIMONY TO THE BOARD OF INQUIRY: http://www.wnho.net/dr_olney1.doc

IN THIS "REPORT FOR SCHOOLS", LAST ARTICLE, IS DR. JOHN OLNEY'S STUDY ON GLUTAMATE AND ASPARTATE WHICH IS IN ASPARTAME: click here

__________________________________________

Whereas, Dr. John Olney stated that it warranted special emphasis that excitotoxins act by an acute but silent mechanism, requiring only a single exposure for CVO neurons to be quietly destroyed, that clearly Searle failed to establish the safety of their product, aspartame, for use in children's food, and that all age comparative data support the following conclusions:

(1) orally administered excitotoxins destroy CVO neurons at any age; (2) immature animals are most vulnerable; and (3) the toxic threshold increases only gradually between birth and adulthood; and

DR. JOHN OLNEY REPORT: http://www.wnho.net/dr_olney1.doc
_________________________________________

Whereas, in 1980, the Public Board of Inquiry unanimously voted against aspartame approval, but was overruled by a new United States Food and Drug Administration Commissioner, Dr. Arthur Hull Hayes, against the advice of Food and Drug Administration scientific personnel and advisers; and Whereas, the United States Food and Drug Administration approved aspartame use in sodas, despite the fact that the National Soft Drink Association argued vehemently against aspartame in these quotes from their protest:

(1) The present record does not contain data which demonstrate that the use of APM in soft drinks will not result in the adulteration of the beverages under Section 402(a)(3) of the FDC Act 21 U.S.S. 342 (a)(3), which provides that a food is adulterated if it contains, in whole or in part, a decomposed substance or it is otherwise unfit for food); (2) An important decomposition product of aspartame, aspartic acid,cannot be detected at all using TLC; (3)G.D. Searle and Company has not demonstrated to a reasonable certainty that the use of aspartame in soft drinks, without quantitative limitations, will not adversely affect human health as a result of the changes such use is likely to cause in brain chemistry and under certain reasonably anticipated conditions of use; and (4) Specifically, Searle has not met its burdens under section 409. To demonstrate that aspartame is safe and functional for use in soft drinks. Collectively, the extensive deficiencies in the stability studies conducted by Searle to demonstrate that aspartame and its degradation products are safe in soft drinks intended to be sold in the United States, render those studies inadequate and unreliable. Senate Congressional Record, May 7, 1985, S5507-5511: and

___________________________________
CONGRESSIONAL RECORD OF 1985:

http://www.wnho.net/congressional_record1.doc

ENTIRE DOCUMENT. TO READ JUST THE PROTEST OF NSDA IT IS COPIED IN THIS LETTER:
http://www.wnho.net/open_letter_dick_adamson.htm

BOARD OF INQUIRY REPORT THAT REVOKED THE PETITION FOR APPROVAL OF ASPARTAME:
http://www.mpwhi.com/fda_petition1.doc

REGARDING HAYES OVER-RULING THE BOARD OF INQUIRY, DISCUSSED IN THE BOOK RUMSFELD, HIS RISE, FALL AND CATASTROPHIC LEGACY BY ANDREW COCKBURN, PAGE 67.
_____________________________________

Whereas, the United States Food and Drug Administration has compiled a list of ninety-two symptoms attributed to aspartame consumption including four types of seizures, coma, and death; and

HERE IS THE FDA LIST OF 92 SYMPTOMS ON THEIR STATIONERY: www.mpwhi.com/92_aspartame_symptoms.pdf
___________________________________

Whereas, the Ramazzini Studies by the European Foundation for Oncology in Italy conducted exhaustive studies over three years with thousands of rats, and proved aspartame to be multipotential carcinogen, thus confirming the United States Food and Drug Administrations original findings; and

RAMAZZINI STUDY:
http://www.ehponline.org/docs/2005/8711/abstract.html

THIS WAS PEER REVIEWED BY 7 WORLD EXPERTS. THIS RAMAZZIN REPORT WAS ALSO POSTED ON THE WEBSITE FOR THE NATIONAL INSTITUTE OF HEALTH, A BRANCH OF THE UNITED STATES GOVERNMENT.
________________________________

Whereas, the United States Food and Drug Administration admitted that aspartame caused cancer over two decades ago when the Administrations toxicologist, Dr. Adrian Gross, told Congress at least one of Searles studies has established beyond any reasonable doubt that aspartame is capable of inducing brain tumors in experimental animals and that this predisposition of it is of extremely high significance. In view of these indications that the cancer causing potential of aspartame is a matter that had been established way beyond any reasonable doubt, one can ask: What is the reason for the apparent refusal by the FDA to invoke for this food additive the so-called Delaney amendment to the Food, Drug, and Cosmetic act? Given the cancer causing potential of aspartame, how would the FDA justify its position that it views a certain amount of aspartame as constituting an allowable daily intake or safe level of it? Is that position in effect not equivalent to setting a tolerance for this food additive and thus a violation of that law? And if the FDA itself elects to violate the law, who is left to protect the health of the public?

Congressional Record, August 1, 1985, SID835: 131:
and THIS GIVES THE REFERENCE TO THE CONGRESSIONAL RECORD.
______________________________________
Whereas , aspartame is linked to sudden death, multiple sclerosis, lupus, and many neurodegenerative diseases, as cited in many medical texts, most notably: Aspartame Disease: An Ignored Epidemic, by H.J. Roberts, M.D., and Excitotoxins: The Taste That Kills, By Russell Blaylock, M.D., and

SUDDEN DEATH: http://www.wnho.net/aspartame_and_arrhythmias.htm

H. J. Roberts, M.D., http://www.wnho.net/aspartame_msg_scd.htm

RUSSELL BLAYLOCK, M.D., MULTIPLE SCLEROSIS: click here

BLAYLOCK AND ROBERTS LUPUS: http://www.wnho.net/aspartame_murders_infants.htm
FOURTH PARAGRAPH, JAMES BOWEN, MD
___________________________________

Whereas, on November 3, 1987, Dr. Louis Elsas told Congress: I am a pediatrician, a Professor of Pediatrics at Emory and have spent twenty-five years in the biomedical sciences, trying to prevent mental retardation and birth defect caused by excess phenylalanine, and therein lies my basic concern, that aspartame is in fact a well known neurotoxin and teratogen which, in some as yet undefined dose, will irreversibly in the developing child or fetal brain, produce adverse effects: and

DR. ELSAS TESTIMONY IS DISCUSSED IN THE UPI INVESTIGATION: http://www.wnho.net/upi_1987_aspartame1.htm

THIS WAS IN THE NOV 3, 1987 CONGRESSIONAL RECORD, AND THE ACTUAL PAGE WILL BE FAXED.
____________________

Whereas, there are tens of thousands of case histories and anecdotal accounts from victims of aspartame poisoning who have come forward to make their case histories known; now, therefore,

WE HAVE THESE AT MISSION POSSIBLE BEING TAKEN IN THE LAST 17 YEARS, AS WELL AS THOSE THE FDA ADMITS TO, AND THEY ARE BEING COLLECTED BY MISSION POSSIBLE CHAPTERS IN 38 NATIONS.
_________________

BE IT RESOLVED by the Senate of the Twenty-Fourth Legislature of the State of Hawaii, Regular Session of 2008, the House of Representatives concurring, that the Department of Health is requested to create, within their existing budget, an evidentiary repository accessible to the public for patients and physicians to submit of the next year their cases involving victims of aspartame poisoning; and

BE IT FURTHER RESOLVED that the Director of Health is requested to report to the Legislature on the status of the evidentiary repository during periodic interim meetings with the Chairs of the Hawaii State Senate Committees on Health and Human Services and Public Housing, the House of Representatives Committees on Health and Human Services and Housing, and the state Attorney General; and

BE IT FURTHER RESOLVED that the Department of Health is requested to review all existing reports, studies, experiments, and related literature on aspartame, including clinical studies, differentiating each study by its funding source, and submit a report to the Legislature no later than twenty days prior to the convening of the 2008 Regular Session; and

BE IT FURTHER RESOLVED that the Nation Academy of Sciences is requested to review all existing reports, studies, experiments, and related literature on aspartame, including clinical studies, differentiating each study by its funding source, and that, if funding is required to undertake this extended evaluation, that the appropriate funding be sought from various foundations and from Congress; and

BE IT FURTHER RESOLVED that given the enormous amount of evidence that has been compiled concerning the neurodegenerative harm it can cause, that the United States Food and Drug Administration is requested to rescind approval of aspartame immediately on a phase-out basis over six months to one year; and

BE IT FURTHER RESOLVED that certified copies of this Resolution be transmitted to the members of Hawaii's Congressional Delegation, the Commissioner of the United States Food and Drug Administration, the Executive Director of the National Academy of Sciences, the Director
of Health, the Director of Human Services, the Attorney General, and the Director of Commerce and Consumer Affairs.

___________________________________________________________________

Contacts for Dr. Betty Martini, D.Hum, Founder,
Mission Possible International,
mailto:BettyM19@mindspring.com BettyM19@mindspring.com and

Stephen Fox, stephen@santafefineart.com

For more information on aspartame:
http://www.mpwhi.com http://www.wpwhi.com
http://www.whno.net
http://www.dorway.com

Aspartame Toxicity Center: click here

Aspartame Information List:

Authors Website: www.unitednationsundersecretarygeneralfornutrition.org

Authors Bio: Stephen Fox is an art dealer from Santa Fe, founder of New Millennium Fine Art, an eclectic Santa Fe gallery since 1980. Active in international and Legislature Democratic politics, he is working towards a ban on Aspartame and the establishment of a New Mexico Nutrition Council, with powers to question and even challenge the FDA. He was a "snowball-in-hell" candidate for the US Senate in 1978, and has been deemed by a Taos newspaper as a "professional idealist," from the M.K. Gandhi/Eleanor Roosevelt wing of the Democratic party. He is presently the Managing Editor of the Santa Fe Sun News, a very alternative twice monthly newspaper based in the capitol of the Land of Enchantment. He cordially invites all Op Ed News readers to visit New Mexico in 2008!



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