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Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

  • Andrew F. Read ,
  • Susan J. Baigent,
  • Claire Powers,
  • Lydia B. Kgosana,
  • Luke Blackwell,
  • Lorraine P. Smith,
  • David A. Kennedy,
  • Stephen W. Walkden-Brown,
  • Venugopal K. Nair
  • Published: July 27, 2015
  • DOI: 10.1371/journal.pbio.1002198

Abstract

Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.

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Recently headlines were made as 118 oncologist, of the 22,125 currently active in the United States, sounded the alarm publicly about the rising price of cancer drugs calling them “unsustainable.” This rebellious 118, or half of one percent, appear to be making a valid argument from within a tightly controlled and highly profitable cancer industry. Perhaps unaware to most oncologist and others within the mainstream medical system is that drug companies rely on fraud and half truths to circulate their products. In fact, most major drug companies have repeatedly shown that profit margins trump empathy, true healing and human life 8 days a week.

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The following open letter by a PhD Immunologist completely demolishes the current California legislative initiative to remove all vaccine exemptions. That such a draconian and cynical state statute is under consideration in the ‘Golden State’ is as shocking as it is predictable. After all, it was mysteriously written and submitted shortly after the manufactured-in-Disneyland measles ‘outbreak’.


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Health Impact News Editor Comments

Dr. MaryAnne Demasi’s documentary on the criminal activity of the pharmaceutical industry regarding cholesterol-lowering statin drugs sent shock waves through the mainstream media in Australia last year. Published in two parts on the popular news show The Catalyst, the pharmaceutical industry complained loudly after the first show, and requested the network not air the second episode, “Heart of the Matter Part 2 – Cholesterol Drug War.”

ABC Australia aired it anyway, but the pharmaceutical influence is apparently too strong, as it was announced that the network would remove the videos from their website because “they breached its impartiality standards.” They also removed them from YouTube.


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Waning of Maternal Antibodies Against Measles, Mumps, Rubella, and Varicella in Communities With Contrasting Vaccination Coverage

Sandra Waaijenborg1,3, Susan J. M. Hahné1, Liesbeth Mollema1, Gaby P. Smits2, Guy A. M. Berbers2, Fiona R. M. van der Klis2, Hester E. de Melker1, Jacco Wallinga1


Correspondence: Sandra Waaijenborg, PhD, National Institute of Public Health and the Environment, Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, PO Box 1, 3720 BA Bilthoven, the Netherlands (sandra.waaijenborg@rivm.nl).
Presented in part: European Society for Pediatric Infectious Diseases, The Hague, the Netherlands (poster) June 2011. Partly presented as a poster at the Nordic Vaccine meeting, Copenhagen, 5–7 September 2012.
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Really Bad Science

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The media often feeds people misinformation about medical science. Leading the deception are the so-called skeptics who claim to be hard-headed scientists.

One leading promoter of skeptic “science” is the physician Ben Goldacre. I took note of Ben Goldacre when he nominated meta-analysis as his Moment of Genius for the BBC. The BBC were asking people to describe their favorite turning point in the history of science. His choice might be described as Goldacre’s Error. One of the most egregious recent mistakes in medical science, meta-analysis is a sham way of presenting subjective information. Meta-analysis makes it possible to select the available data and get the answer you want. Selecting data is one of the biggest errors a scientist can make.

Let’s use Ben Goldacre’s book Bad Science to show how this works. I consider this book well named – it is very bad science indeed.

Here is an example of how Goldacre misleads by selecting his data. He begins by giving a graph of increased life expectancy in the UK covering the previous century.

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Is the fog a source of drought relief?

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Is the fog a source of drought relief?


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Studies ‘supporting’ Andrew Wakefield

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It is 15 years since Andrew Wakefield first hypothesised a link between the MMR vaccine and autism in children, mediated by an inflammatory bowel condition (subsequently labelled ‘autistic entercolitis’). Over this period Dr Wakefield and his supporters have cited a range of studies which are claimed to ‘verify’, ‘replicate’ or ‘support’ his MMR-autism theory. Here is the most recent list:

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CANCER: Nagalase in Blood

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Nagalase in Blood

Test for monitoring efficacy of therapy for cancer and certain viral infections

Nagalase in serum / plasma

The test measures the activity of an enzyme α-N-acetylgalactosaminidase (nagalase) in blood.

Nagalase is an extracellular matrix-degrading enzyme that is secreted by cancerous cells in the process of tumor invasion. It is also an intrinsic component of the envelope protein of various virions, such as HIV and the influenza virus. Thus, it is also secreted from virus-infected cells1,3,4.

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UN WHO File Reveals Dual Purpose of Eugenics Vaccines

For the uninitiated who will see this type of information for the first time and chalk it up to conspiracy … we strongly urge you to read through the article and the associated links. Just because information is made available to you in a blatant (in your face) fashion, and may make you uncomfortable, is not a good reason to doubt its validity, or dismiss it out of hand.

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