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Aspartame Cancer Risks Revisited Prenatal Exposure May Be Greatest Concern

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EHP Science Selections highlights 2nd Ramazzini study: "Aspartame Cancer Risks Revisited Prenatal Exposure May Be Greatest Concern"

A second Ramazzini bioassay on aspartame “Lifespan Exposure to Low Doses of Aspartame Beginning During Prenatal Life Increases Cancer Effects in Rats” was published in the September 2007 issue of Environmental Health Perspectives [EHP 115:1293–1297; Soffritti et al]. The issue also includes a Science Selections feature story on the Ramazzini project [EHP 115:A460] .

The Ramazzini study is a follow-up to a 2006 publication entitled “First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats” [EHP 14:379–385; Soffritti et al] .

The results of this second long-term carcinogenicity bioassay not only confirm but also reinforce our first experimental demonstration of APM’s multipotential carcinogenicity at a dose level close to the human ADI. Furthermore, the study demonstrates that when life-span exposure to APM begins during fetal life, its carcinogenic effects are increased.
Environmental Health Perspectives (EHP) is the peer-reviewed journal of the United States' National Institute of Environmental Health Sciences. With an impact factor of 5.86, EHP ranks first among 132 environmental sciences journals and first among 90 public, environmental, and occupational health journals. EHP is read in over 190 countries.

Ramazzini press contact
Kathryn Knowles

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