Aids and Arteries - The smooth muscle CD4 connection
First off, I have radical ideas, so will have to describe them to get to the reasons why I see HIV as an arterial retrovirus.
I believe that viruses and retroviruses are in our genome.
When someone gives you a virus it's a 'viral outbreak' from their own DNA.
If you have exposed DNA then the symptoms are simply caused by insertions of someone else's DNA into yours.
The cure being make sure your cell walls are healthy and you don't have exposed DNA.
These thoughts are from literally a decade of looking at studies in PubMed.
While other folk have been checking out reality TV and insane Youtube clips and chatting about inane things online I've been perusing studies so I'm not very hippy about this.
If I'm saying this is 'what the?' data you have to deal with the fact that I may be pointing at something very awkwardly real when interpreted into the real world.
So Herpes viruses in particular have this dalliance with collagen and get blamed as a cofactor in all the degenerative diseases like Heart Disease, Arthritis and Multiple Sclerosis.
Almost everyone with a brain tumour has had mouth Herpes or cold sores, why?
But cancer researchers can also use Herpes viruses to dismantle a tumour from the inside .
So it's like Herpes was meant to break down collagen and expose DNA for digestion?
Who knows?
Herpes viruses and other viruses seem to appear magically after DNA damage.
You have Herpes infections of eyes post laser surgery and following sunburn.
Shingles can happen after sunburn....
Chemicals, heavy metal exposure, some drugs, radiation exposure and bad diet all leads to DNA exposure and this looks like the main source of our viral outbreaks.
The big 'what the' for me though is the spontaneous eruptions of cytomegalovirus when women get pregnant.
Time and time again I would read researchers say 'we don't know the source of the cytomegalovirus infection?'
Well viruses have a dalliance with arterial changes as well as collagen so when women get pregnant it looks like cytomegalovirus dismantles old unwanted arteries.
Unwanted because the baby is about to pinch 40% of the mum's blood supply so the old arteries are just way too small for the job.
But retroviruses also seem to appear in this process after T-cells and white blood cells remove old dead cellular debri.
After as in it seems the retroviruses appear with the new growth?
This is why they turn up with the placenta and tumour cells and all the areas where people with autoimmune disease have lesions or damaged cells in the process of trying to repair the body structure.
They also say reverse transcriptase is used by retroviruses but it is really a measure of cell growth.
Just type in "reverse transcriptase cell growth" into a google.
So my explanations say for Ebola would be that since most Ebola outbreaks seem to occur within 2 years of a Measles vaccine campaign the live Measles virus they use in Africans who are low in Vitamin C, Lysine and Selenium causes an unravelling of DNA from the inside of people and without enough Vitamin C and Lysine to create collagen and make antibodies a person continues to unravel.
Here in Queensland Australia we have an outbreak of a so called horse virus called 'Hendra Virus' which they blame bats for passing on to horses via their excrement.
In my book the obvious cause then is pesticides, the bats eat fruit laden with poison that damages their DNA and cells, the dying cells express exposed DNA.
That exposed DNA can be picked up by the horses who may or may not deal with stabilising their DNA before the unravelling becomes deadly.
In the modern world we are now getting exposed to drugs, heavy metals, pesticides, GMO's, preservatives, colourings, fluoride, benzene from petrol, radiation from thousands of sources plus the odd leaking nuclear power plant etc.
This exposes our DNA so expect more viral outbreaks.
Solar storms and positively charged winds also give people the sort of radiation and electrical changes that expose DNA.
In short exposed DNA is dangerous.
I see the mass culling of cows say with mad cow disease as happened as medieval.
The same goes for the slaughter of millions of birds 'infected' with bird flu.
The cows got mad cow from organophosphate insectides, well known for causing brain damage
If you just let the birds get the flu some will get over it and some won't.
Dressing up in white suits and culling animals in a bizarre ritual to cleanse the world is a cult like activity.
You just don't eat the poor animals until they get well again.
If a researcher wants to experiment with this all you need to do is scrape off some of your own cells.
Dissolve your cells in Benzene and let it evaporate, this will wreck the cell walls and expose your DNA.
Then expose the muck and DNA to a hypomethylating chemical which will expose DNA further.
You then leave it in an Arginine solution to destabilise the Histones.
Leave it all in a positive ion chamber and I'll bet you watch viruses grow out of your DNA.
Has anyone tried it?
Now I am going to use quotes from Alfred Hassig, the former president of the Board of Trustees of the International Society of Blood Transfusion between 1982 and 1984.
In other words the head of the Swiss Red Cross Transfusion Service.
He said and I repeat in memory of all those frightened and poisoned to death by this shoddy HIV science.
"It is the duty of every medical doctor to preserve life at any cost - the Hippocratic Oath - and not death-curse people based on any test so they are so frightened they kill themselves. I am sad to say that these voodoo methods were practised despite there never being any proof that the detected antibodies - suggested as specific to a retrovirus - are an indication of mortality in all diagnosed people."
This is the quote that puts in context my description of HIV as an arterial retrovirus.
The immune system itself is not all about foreign invaders.
If you have healthy intact cell walls and a clean water supply bugs should be a minimal problem for the immune system.
The main thing the immune system must deal with now is sugar and fat and all the poisons we use habitually since we became fans of science.
"The human immune system was conceived of only in its function against foreign (non-self) structures. The Nobel laureates Burnet, Medawar and Jerne have completely neglected the main function of the human immune system. The human organism dismantles about 1 billion body cells every day. One part of our immune system - the T-cells from the Thymus gland - is in charge of cleaning up this altered-self material. In a healthy organism the immune functions of antibodies produced by B-cells, and of the cytotoxic or cell-clearing T-cells, remain in balance."
I have an autoimmune drama in that my T-cells can get a bit excited and if they get out of control can really rip my skin to shreds.
Hence my memories of my 'immune' system are of my entire outer skin layer being removed by thousands of burning white blood cell clusters until all the Benzene and Nitrate chemicals I had been exposed to were gone with the dead skin.
It's called a cytokine storm and people can die from it in so in hospital they just dole out corticosteroids to stop the immune system from dissolving you.
I use Bromelain now and the odd dab of corticosteroid cream.
The main pattern of AIDS goes like this.
Poison exposure from recreational or doctor drugs.
Immune overload and autommune symptoms as the body's T-cells try to clear the clutter.
This is then suppressed with corticosteroids which switch off the T-cells so the T-cells job in removing dead cells and poisons with white blood cells just stops and people clog up and die.
But Alfred also asked "why are Africans always HIV positive?"
"I was invited as an expert by the Supreme Court in Melbourne, Australia, to comment on whether the blood product Factor VIII used by people with haemophilia, could possibly transmit HIV, in 1990. I had to consult the scientific literature on AIDS. I found inaccuracies in the 'HIV/AIDS' statistics compared with the reality in different countries. I was especially attentive to the fact that AIDS diagnoses in Africa seemed common; in Asia however - despite the high incidence of so-called HIV-positivity - there were relatively very few AIDS diagnoses. One particular study caught my attention. It was carried out in Trinidad. From the almost equal numbers of positive Afro-Trinidadians and Indo-Trinidadians - each about 40%, with both about the same percentage of homosexual activity - only the Africans died with AIDS diagnoses. Why? As an immunologist focusing on nutrition I soon realised the specific nutritional components. Asians have a highly antioxidative diet, for example with curry. These findings caused serious doubts whether the perceived AID Syndrome was being sufficiently explained by "HIV".
Well Africans seem to have more HLA-DR antigens either from having sickle cell anemia or some other historical genetic reason....
Or simply from more heart disease due to dietary differences as Alfred just said.
And AIDS tests are applied to "At risk groups"
Our own doctors may be simply creating an 'epidemic' by testing the same people over and over again...
...but this below is what I think the testing really meant.
It looks like an acute infection with 'HIV" is only occurring when arteries have remodelling and or lesions.
It resides in HLA-DR+ cells which appear in the arterial lesions.
HLA-DR+ also can cause apoptosis of Leukemic T-cells so if someone has Leukemia the HIV budding from the HLA-DR+ cells may be doing the desired thing off knocking off T-cells before they kill you.
HLA-DR may also be a way to make smooth muscle cells undergo apoptosis or commit suicide to move out of the way for new smooth muscle cells.
With placental movement the HLA-G at the trophoblast interface make endothelial cells shut up shop.
CD4 T-cells are T-cells to remove arterial plaque, not immune cells.
Africans may be at more risk due to heart disease which is why they test positive more frequently.
"The most surprising finding in the plaque was the high frequency of T lymphocytes, which were virtually absent from normal human arteries."
"In this study, we demonstrate that class II MHC antigens appear in human atherosclerotic plaques.
Immunocytochemical analysis of tissue sections indicated that DR had a more widespread distribution than DQ, and examination of serial sections suggested that plaque cells either expressed both antigens, or only DR.
In contrast, class II antigens rarely appeared on cells of normal arteries.
DR and DQ were both present on smooth muscle cells, which do not express class II antigens in normal blood vessels."
Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain
The reason pregnant women don't always come up HIV+ is because the predominant HLA type in pregnancy is HLA-G.
HLA-G is associated with HERV-W.
HERV-W is a normal retrovirus in mothers needed to divert blood to the fetus.
HLA-G is the MHC that appears at the trophoblast interface along with HERV-W.
It's only women with Rheumatism and Antiphospholid Antibodies who test HIV+ because the test picks up HLA-DR antibodies that appear in arterial lesions.
HLA-G and HERV-W appear together in Multiple Sclerosis also and schizophrenia.
This is to do with microglia taking out damaged nerves and HERV-W also makes Brain Derived growth factor kick in so it's about new growth?
HERV-W may also be vital in the fetus for proper nerve growth?
Whatever it all means the cure is just good nutrition.
"HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors. Identification of these antigens has led to greater success and longevity in organ transplant.
HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease.
HLA-DR molecules are upregulated in response to signalling. In the instance of an infection, the peptide (such as the staphylococcal enterotoxin I peptide) is bound into a DR molecule and presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation."
http://en.wikipedia.org/wiki/HLA-DR
Quoting Alfred again
"The human organism dismantles about 1 billion body cells every day. One part of our immune system - the T-cells from the Thymus gland - is in charge of cleaning up this altered-self material."
So HLA-DR seems to be tagging damaged cells for removal?
I'll repeat concepts...
What I would say now is HLA-DQ has the HERV-K's retroviruses
" Two endogenous retroviral long terminal repeats (LTRs) were found in the human major histocompatibility complex locus HLA-DQ."
"These elements exhibit >90% homology to the LTRs of the human endogenous retrovirus HERV-K10."
Endogenous retroviral long terminal repeats within the HLA-DQ locus
and HIV is with the HLA-DR antigens.
Incorporation of HLA-DR into the Envelope of Human Immunodeficiency Virus Type 1 In Vivo: Correlation with Stage of Disease and Presence of Opportunistic Infection
http://jvi.asm.org/cgi/content/full/74/21/10256
blah blah....
But this is all about arterial changes and so therefore folk with more HLA-DR genes such as Africans end up with heart disease and all the HIV tests come up bingo.
HLA-DR+ antibodies cross react with the p24 part of the HIV antibody test so folk carrying the HLA-DR genes that get arterial changes will be positive.
Leukemic T-cells go p24 too but they may also be folk with HLA-DR+
"This study demonstrates that DR expressed on CD4+ T cells dramatically increases HIV-1 expression. Virus production in DR+ cells was > 10-fold higher than in DR- cells as measured by p24 production. Moreover, two T cell lines that were derived from the same parental cell, one DR+ and the other DR-, differentially expressed HIV-1 following transfection with full-length HIV-1 clone as determined by luciferase.
Viral expression in DR+ transfectants were up to 20-fold higher than the DR- counterparts."
HLA-DR on T cells enhances HIV-1 expression.
But you see HLA-DR and the CD4 T-cells in arterial changes ....
"HLA-DR was expressed on 28% (range 16-42%) of all T lymphocytes in the wall of the inflamed temporal artery, but only on average on 6% of peripheral blood T lymphocytes, indicating a
high degree of local T cell activation in the inflammatory lesion."
HLA-DR expression in the vascular lesion and circulating T lymphocytes of patients with giant cell arteritis
"HLA-DR expression was more often seen in macrophages and T cells in ruptures (25 of 28 cases) compared with expression in macrophages in superficial erosion arteries "
Coronary Plaque Erosion Without Rupture Into a Lipid Core.
A Frequent Cause of Coronary Thrombosis in Sudden Coronary Death
"The massive expression of HLA-DR antigen on mononuclear cells was found in the lesions. In addition, the HLA-DR activation antigen was expressed on the coronary arterial endothelium at the infiltrates in which macrophages and T cells coexisted."
Kawasaki is just acute heart dysfunction when low Vitamin C and Lysine levels occur with low Glutathione, as with cancers, arterial lesions hypomethylate from loss of nutrients and DNA exposure so there is a good chance retroviruses are being expressed in lesions.
"Previous studies have provided clues for possible existence of increased oxidative stress in patients after KD. Deng and colleagues have demonstrated the restoration of systemic arterial endothelial dysfunction in patients with and without coronary aneurysms at 1 to 10 years after initial diagnosis of KD by acute intravenous administration of vitamin C. They hypothesized that the antioxidant action of vitamin C might be responsible for the beneficial effect"
Basically everything with HIV and CD4 T-cells is about arterial changes which is what I started writing questions about this year.
AIDS: CD4 T-Cell Test is a Measure of Fat
http://www.laleva.org/eng/2011/02/aids_cd4_t-cell_test_is_a_measure_of_fat.html
Anyone using poppers, cocaine, uppers like speed, meth, ecstasy, viagra will expand arteries and if you have HLA-DR genes it puts you at risk of being HIV+.
Pregnant women have massive retroviral involvement and arterial changes so they too if HLA-DR will be at risk from the test.
What do retroviruses do when pregnant?
http://www.laleva.org/eng/2011/06/what_do_retroviruses_do_when_pregnant-print.html
Same goes for cancers and autoimmune disease which both have retroviral involvement and arterial changes.
Smokers and even folk who drink too much red wine have arterial changes that could cause what looks like a massive expression of retrovirus as plaque is broken down and smooth muscle cells fill the gaps in the arterial lesions.
This is why Italian men who drink Myrtle wine high in polyphenols get Kaposi's cancer.
Kaposi's is cancer of endothelial cells which is why HHV8 is associated, HHV8 may have a purpose but I haven't worked it out yet.
Cytomegalovirus is the herpes that seems to sit in smooth muscle cells but I don't know why again.
This is why HIV makes smooth muscle cells express and grow and cytomegalovirus appears spontaneously with the arterial expansion you see in pregnant women.
Sports people are also at risk from the HIV test due to arterial expansion and low fat levels which lower their T-cells.
Africans are just starving and drinking filthy water with real bugs.
Basically almost everyone is HIV+ but this is only reduced by diluting the HIV antibody test 400 times
But all of this is about arteries.
"Conclusions - Smooth muscle cells expressing HLA-DR are abundant downstream, providing an explanation for the known distal plaque growth. In contrast, the recruitment of macrophages, T cells, and mature DCs, directed by their expression of chemokine receptors responding to local chemokines, through neovessels into the upstream shoulder, might contribute to plaque destabilization by HLA-DR expression."
Flow-Dependent Accumulation of Inflammatory Cells in the Upstream Shoulder of Atherosclerotic Plaques
And that is where you find HIV.
But if HLA-DR and HIV disappear from healthy arterial lesions then the cure is to fix heart disease plus the iron overload you see feeding real infections.
You must have Vitamin C and Lysine and Glutathione for Heart Disease and these also happen to be antivirals.
You also need Folic acid, Selenium and B12 and B6 to methylate arterial lesions and fix the arterial walls.
I think Bromelain will sort inflammation, it can replace any blood thinner and safely.
Sage tea is my choice for fixing blood and antiphospholid problems as it fixes a lot of this...
"No adverse effects were reported. The results suggest that sage may be effective and safe in the treatment of hyperlipidemia"
Antihyperlipidemic Effects of Salvia officinalis L. Leaf Extract in Patients with Hyperlipidemia
Vitamin D I believe is of vital importance, without it the immune system and arterial and nerve development can go off track.
If a HIV test means a syndrome of arterial disease and antibodies to our arteries as in antiphospholipid syndrome then we have all the means to fix it.
"Owing to the well-known role of vitamin D(3) defect in autoimmune disease, the detection of vitamin plasma levels in APS patients will offer the rationale for a possible therapeutic supplementation.
European Forum on Antiphospholipid Antibodies: research in progress.
This is really important to Africans who don't get enough sun either in Northern winters or South African winters too...
"Why African Americans, with their low vitamin D blood levels, are more likely to die from influenza and pneumonia than Whites are....
...as vitamin D deficiency has repeatedly been associated with many of the diseases of civilization, we point out that it is not too early for physicians to aggressively diagnose and adequately treat vitamin D deficiency. We recommend that enough vitamin D be taken daily to maintain 25-hydroxy vitamin D levels at levels normally achieved through summertime sun exposure (50 ng/ml). For many persons, such as African Americans and the elderly, this will require up to 5,000 units daily in the winter and less, or none, in the summer, depending on summertime sun exposure."
Epidemic Influenza And Vitamin D
This has happened to me for a decade where if I don't get sun while working in winter I can end up with a skin fever and skin rashes, my fix is cod liver oil and it works every time to stop it.
Hope folk think about it.
Comments
October 4, 2011 11:07 AM | Posted by: cal crilly
thanks (: this is just a piece to put questions out there....
There is a lot in this that people who own labs need to work out.
As for the fix.
You need vitamin c and lysine and glutathione for heart disease and these are also antivirals.
you also need folic acid and B12 and B6 to methylate arterial lesions and fix the walls.
I think bromelain will sort inflammation.
Sage tea is the choice for fixing blood and antiphospholid.
Hope folk think about it.