Joel M. Kauffman, Ph.D.
Professor of Chemistry Emeritus
Philadelphia, PA, USA
Abbreviations: CVD - Coronary Heart Disease; FH - Familial Hypercholesteremia; HDL - High Density Lipoprotein; HPS - Heart Protection Study; LDL - Low Density Lipoprotein; NO - Nitric Oxide; RR - Relative Risk; TC - Total Cholesterol
The statin drugs are essentially the HMG-CoA reductase inhibitors: atorvastatin (Lipitor™), cerivastatin (Baycol™, withdrawn 8/01), fluvastatin (Lescol™), lovastatin (Mevacor™), pravastatin (Pravachol™), simvastatin (Zocor™), pitavastatin and rosuvastatin (Crestor™), which were introduced to lower total cholesterol (TC) levels, and especially LDL-cholesterol (LDL) levels, ostensibly to prevent coronary heart disease (CVD).