Under Pressure Glaxo Publishes Paxil Data
Wed Jun 16, 2004 03:09 PM ET
Source: Reuters

NEW YORK (Reuters) - GlaxoSmithKline Plc (GSK.L: Quote, Profile, Research) , responding to a lawsuit claiming it suppressed negative data about its antidepressant Paxil, published results of trials showing the drug is broadly ineffective in children and adolescents and could increase risks of suicidal behavior.

The British drugmaker released data from nine pediatric trials on its Web Site after New York Attorney General Eliot Spitzer filed suit two weeks ago accusing Glaxo of fraudulently suppressing the information.

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Fluoridated Water & Infant Formula

 FAN Science-Watch
May 6, 2004

Bulletin #9: Fluoridated Water & Infant Formula

by Michael Connett
Editor, FAN Science-Watch

Source: Fluoride Alert Network

The use of fluoridated water in infant formula is in the news.

Yesterday, Reuters published an article on a study from the Journal of the American College of Nutrition which found that consumption of beverages (particularly infant formulas reconstituted with fluoridated water) is associated with an increase of dental fluorosis in a baby’s primary teeth.

Reuters’ article comes on the heels of a press release issued by the New York State Coalition Opposed to Fluoridation (NYSCOF) addressing the same study.

While the authors of the study do not overtly challenge fluoridation policy, they do tip-toe into interesting terrain: namely, the potential need to restrict the use of fluoridated water in infant formula.

To quote:

“Our results suggest that the fluoride contribution of water used to reconstitute formulas increases risk of fluorosis and could be an area for intervention.”

“Supporting long-term lactation could be an important strategy to decrease fluorosis risk of primary teeth and early developing permanent teeth.”

“Fluoride concentrations of both human milk (0.005–0.010 ppm) and cows’ milk (0.03–0.06 ppm) are low, and consumption of either human milk or cows’ milk could decrease fluorosis risk.”

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First Citizen's Conference on Fluoride
Source: Enviromental News Network


From Fluoride Action Network
June 16, 2004

FIRST CITIZEN'S CONFERENCE ON FLUORIDE
(July 30-August 2, 2004)

Co-sponsored by:
FLUORIDE ACTION NETWORK
and
HAUDENOSAUNEE ENVIRONMENTAL TASK FORCE
(Mohawk, Oneida, Onondaga, Cayuga, Seneca, Tuscarora)

The First Citizens' Conference on Fluoride will be held at St. Lawrence University, Canton, New York, and at the Mohawk Nation Longhouse at Akwesasne, near Massena NY.

The conference has been convened to enable citizens, environmentalists, and those working in the public health and regulatory sectors to learn firsthand about the toxicity of fluoride and its adverse effects on humans and the environment. Presentations by scientists and researchers will be targeted to a citizen audience.

Concerns about fluoride's toxicity are heightened by results from numerous published studies in the last 8 years reporting serious effects from fluoride exposure, including adverse effects on: the brain, bone, male reproductive system, kidney, liver, lung, thyroid, and G-proteins (an important mechanism that controls critical intracellular communication).

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P A N U P S -Pesticide Action Network Updates Service
Two New Warnings on Pesticides & Chemicals
June 15, 2004

In April, Canadian family physicians issued a strong warning on the risks of exposure to pesticides, noting the number of studies linking cancer, reproductive problems and neurological diseases with commonly used pesticides. The following month in Paris, medical specialists from Europe, Canada and the U.S. released an International Declaration on Diseases Due to Chemical Pollution, calling the number of untested chemicals in the environment "a serious threat to children and to Man's survival."

The April report by the Ontario College of Family Physicians (OCFP) on the chronic effects of exposure to pesticides contained sweeping recommendations to cut pesticide exposures, including curtailing pesticide use wherever possible, using personal protective equipment including respirators for home and occupational exposures, and urging physicians to advocate for pesticide reduction and screen their patients for pesticide exposure.

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Hospital on Long Island May Have Exposed 177 to Viruses
By PATRICK HEALY
Published: June 16, 2004
Source: New York Times

Nearly 180 patients of North Shore University Hospital in Manhasset were informed last week that they might have been exposed to H.I.V. or the hepatitis virus because instruments used for routine endoscopies might not have been properly disinfected.

Eighty-six of the patients have returned to the hospital, on Long Island, for precautionary blood tests, and none have tested positive for hepatitis or H.I.V., the virus that causes AIDS, a hospital spokesman said yesterday. The New York State Department of Health is investigating the lapse, a spokesman said, but has not taken action against the hospital.

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WHAT REALLY HAPPENED AT THE IOM HEARING?
Source: University Of Health - PRESS RELEASE UNINFORMED CONSENT

 Why did the IOM Report Stun the Scientific Community and Parents?

Report Says No Evidence Mercury In Vaccines/Fillings Related To Epidemic Levels of Autism

UNINFORMED CONSENT, WA DC – In the face of angry parents, shocked scientists and a scathing congressional report from a 3-year investigation stating otherwise, Chairperson Dr. Marie McCormick issued the latest report from the Institute of Medicine’s Immunization Safety Review Committee (ISRC) from a daylong hearing held February 9, 2004.   The report as stated by IOM Committee Chair, Marie McCormick,  “The overwhelming evidence from several well-designed studies indicates that childhood vaccines are not associated with autism.”  

The Institute of Medicine, (IOM) (under the US National Academy of Sciences) heard testimony from 15 experts in a day long “Safety Review” on thimerosal (mercury) levels in vaccines and mercury in dental amalgam that are linked to epidemic levels of autism. 

Whether the CDC, (Centers for Disease Control), (and a fraternity of other government agencies charged with public safety oversight of pharmaceuticals and medical practices), have acted in the best interests of pharmaceutical cartels instead of the public has been the heartbeat of the investigation.

Mike will be talking with UnInformed Consent’s Christy Diemond, executive producer and investigative journalist who was in attendance at the infamous IOM review meeting.   The talk line is: (816) 576-7710.

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Safety alert on adult use of antidepressants

Sarah Boseley, health editor
Monday June 14, 2004
Source: The Guardian

The modern antidepressant drugs which were thought to be a miracle cure for 20th century misery only 10 years ago are expected to suffer a second big blow this year when the UK authorities will warn that some of them can cause adults to become suicidal.

An expert working group of the government's Committee on the Safety of Medicine (CSM) has already warned that all but one of the SSRIs (selective serotonin reuptake inhibitors), including the best-selling Seroxat, should not be given to children. It found that there were risks of children becoming suicidal, aggressive and suffering mood swings, and the drugs were anyway not very effective.

Now the committee is close to completing its review of the safety and efficacy of the SSRIs in adults. The Guardian understands that it has found a similar picture and that the drug regulatory body, the Medicines and Healthcare Products Regulatory Agency (MHRA) is likely to impose restrictions on the use of some of them.

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Group Weighs Plan for Full Drug-Trial Disclosure
By BARRY MEIER
Published: June 15, 2004
Source: New York Times

An organization of top medical journals is considering a proposal that would require drug makers to register clinical trials at their start in a public database in order for results, whether successful or not, to be later considered for publication, according to three people working with the group.

Pharmaceutical companies are not generally required now to disclose results of a trial or even whether one was conducted. Some academic researchers have long argued that fuller registries of drug trials are needed because companies, as well as medical journals and scientists, tend to spotlight only trials that show positive results.

The plan, if adopted by the organization, the International Committee of Medical Journal Editors, is likely to put pressure on pharmaceutical makers to disclose more about the trials they run. The group includes 12 major medical journals like The Journal of the American Medical Association, The New England Journal of Medicine, The Lancet and The Annals of Internal Medicine.

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Vitamin E location in membranes suggests functions beyond anti-oxidant
NewsRx.com
11 Jun 2004

The distribution of alpha-tocopherol in membranes suggests that it possesses functions besides that of an anti-oxidant.

According to recent research from England, "Vitamin E acts as an anti-oxidant and stabilizer of membranes. Other functions of vitamin E unrelated to its effects on membranes are emerging. Vitamin E partitions into the lipid bilayer matrix of membranes. It orients perpendicularly to the plane of the membrane with the hydroxyl group pointing to the lipid-water interface."

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Vitamin B-12 deficiency creates aberrant DNA changes associated with cancer
NewsRx.com
11 Jun 2004

"Derangements of one-carbon metabolism can directly affect the integrity of the genome by producing inappropriate uracil insertion into DNA and by altering patterns of DNA methylation. Vitamin B-12, a one-carbon nutrient, serves as a cofactor in the synthesis of precursors of biological methylation and in nucleotide synthesis. We therefore examined whether vitamin B-12 deficiency can induce these molecular anomalies in the colonic mucosa of rats," scientists in the United States report.

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