Benzene is a rather poisonous substance used as an industrial solvent and added to "green" gasoline. Wikipedia says that this use has been limited, but benzene certainly has not been eliminated from the gasoline we pour into our car when we "fill her up". The substance is also a known carcinogen and as a cause of leukemia. As Cal Crilly details in the following article, benzene may also be implicated in what's known as Aids through the mechanism of DNA methylation.
Here is the article, a joint effort by Cal and his friend Fred, a 70 year old HIV positive with a missing Methylation Gene.
Low dose benzene causes global hypomethylation of DNA and epigenetic hypermethylation of some genes.
The presence of matrix metalloproteineases, MMP's, in benzene toxic patients shows that the extracellular matrix (ECM) has been affected, namely collagen.
Recent research shows that Histone Deacetylase, an enzyme which affects the ECM, is associated with methylation and that Histone Deacetylase Inhibitors (HDAC) can be used to reverse de-acetylation, methylation and the formation of MMP's.
Therefore, it follows that the damage done by benzene to the ECM could be partly reversed by HDAC's.
Since benzene causes collagen damage, it follows that this damage could be due to Histone Deacetylase enzyme which is associated with methylation.
But Benzene also initiates global hypomethylation and as well as hypermethylation epigenetic changes.
So Benzene makes retroviruses come out but triggers Histone Deacetylase.
(As in it is one big cause of cancer that we are doing almost nothing about.)
Hypomethylation can result in DNA or RNA changes.
Latent Herpes viruses are activated by immune activation which Benzene as a toxin would also do.
Benzene toxin would also release parasite egg sacs from collagen in immunocompromised people by ECM oxidation/damage which releases MMP's.
If these eggs have a lipid coating it will be removed by the Benzene allowing the egg sacs to break resulting in chronic parasitic infection.
The combination of immune activation and hypomethylation could result in Histones.
Protease Inhibitors used in HIV-1 protocols are Histone Deacetylase inhibitors and MMP inhibitors.
They are called Protease Inhibitors so over time they would stop the release of parasite egg sacs from the ECM stopping the chronic immune affect of Benzene toxicity.
"Airborne benzene was associated with a significant reduction in LINE-1 (-2.33% for a 10-fold increase in airborne benzene levels; P = 0.009) and AluI (-1.00%; P = 0.027) methylation." Or hypomethylation of LINE-1 retroviral elements.
Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene